• 7 Kasım 2019
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E-cigarette Vapors Can Damage The Lungs Even Without Nicotine

A recent study in mice may shed some light on how electronic cigarettes (e-cigarettes) are harmful, even if they don’t have a nicotine in vapors.

A new study can offer valuable insights into the effects of vaping.
In a study from the Baylor School of Medicine in Houston, Texas, vapors of chronic exposure can negatively affect normal lung function, even if the electronic cigarette is not Nicotine.

This exposure can also cause negativities about how the body responds to infections because it makes the immune cells in the lungs react less to viruses.

Findings also seen Journal of Clinical Research.

As the authors of the new article explain, some studies have suggested that e-cigarettes are harmful to the health of those who breathe themselves. Others, however, noted that these products are safer compared to regular tobacco cigarettes.

“These opposing views on the safety of e-cigarettes led my graduate students, Matthew Madison, to investigate the effects of chronic smoking exposure on e-cigarette vapors and traditional tobacco smoke on lung lung function,” he says. Kheradmand, a pulmonologist and medical professor at the Baylor College of Medicine.

“We also looked at the effect of vapors or smoke on the function of immune cells called macrophages in the lung. These cells represent the first line of defense against virus infections caused by viruses. ”

Vaping solvents, nicotine and lung health

The study consisted of four groups of mice. The researchers exposed a group of e-cigarette vapors containing nicotine and other vapor solvent solvents such as propylene glycol and herbal glycerin.

They exposed another group to the same solvents but did not use nicotine. They exploded a third group for tobacco smoke. The fourth group was able to reach fresh air.


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To mimic the time a person would breathe these substances when they expose mice for 4 months. This roughly corresponds to a smoker from his young age for the fifth decade.

When the researchers examined mice exposed to cigarette smoke, they were not surprised: they saw severe lung damage and inflammation comparable to emphysema. This is similar to what happens when people use tobacco for a long time.

Surprising findings

However, researchers were surprised to learn that mice exposed to nicotine-free evaporating solvents also damage their lungs.

Although it is not the same type of damage they see in mice exposed to tobacco smoke, it has still been an important finding. Although no emphysema-like disease was found, researchers discovered an abnormal accumulation of lipids in the lungs.

This accumulation of oil did not consist solely of the evaporating solvents themselves or oils in liquids. Instead, what happened was “an abnormal turnover of the protective fluid layer in the lungs”.

Researchers found excessive accumulation of lipids in the assistant macrophages Cells working to detect and destroy harmful organisms.

This accumulation prevented macrophages from responding normally to infections. The implication for humans is that a disease will be more likely to have a negative effect rather than having a healthy macrophage population.

“In summary, our experimental findings reveal that, regardless of nicotine, chronic inhaled e-cigarette vapors impair normal murine lung function and decrease the ability of established immune cells to respond to infection and increase susceptibility to diseases such as influenza.

Farrah Kheradmand

“Our experimental findings share the similarities with previous multiple case reports explaining the presence of lipid-laden macrophages in lung fluid from people associated with e-cigarettes.”

Researchers think their findings need to do more research on how e-cigarette vapors affect health, even if people don’t use nicotine products.

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